ABP-7 (Thymosin Beta-4 Actin-Binding Fragment)

Also known as: actin-binding peptide-7, TB-500 fragment, Ac-LKKTETQ

Wellness

In plain English

ABP-7 is a short synthetic peptide (Ac-LKKTETQ) copied from the part of thymosin beta-4 that binds actin, the protein that lets cells move. It is promoted as a smaller "fragment" version of thymosin beta-4/TB-500 for tissue repair. In animal wound studies this small peptide promoted healing similar to the full molecule. Evidence is preclinical; there are no human trials, and it is not FDA-approved.

The science

ABP-7 is a synthetic N-acetylated heptapeptide (LKKTETQ) corresponding to the actin-binding domain of thymosin beta-4 (Tβ4). Tβ4 sequesters G-actin and influences cell migration, angiogenesis, and repair; the isolated LKKTETQ motif reproduces part of this activity. In a controlled study in aged mice, both Tβ4 and the synthetic actin-binding-domain peptide accelerated dermal wound healing, enhancing keratinocyte migration and collagen deposition (Philp et al., 2003). Evidence is preclinical; there are no human clinical trials, and it is not FDA-approved. It is used in the same tissue-repair context as BPC-157 and thymosin beta-4.

References

• Philp D et al., Wound Repair Regen 2003 (Tβ4 and actin-binding-domain peptide promote wound healing)