Niacinamide (Vitamin B3)

Also known as: nicotinamide, vitamin B3 amide

Hair RestoreDermatology

In plain English

Niacinamide is a form of vitamin B3 widely used in skincare. It strengthens the skin barrier, calms redness and inflammation, helps with acne and rosacea, and can lighten dark spots. It is gentle, well tolerated, and pairs well with most other ingredients, which is why it appears in many combination creams.

The science

Niacinamide is a precursor of NAD+/NADPH and modulates cellular energy, DNA repair, and inflammation (in part via inhibition of PARP-1 and NF-kappaB signaling). Topically it stimulates ceramide, free fatty acid, and cholesterol synthesis and structural proteins (filaggrin, involucrin) to improve the permeability barrier, reduces transepidermal water loss, decreases sebum, has anti-inflammatory effects useful in acne and rosacea, and inhibits melanosome transfer to reduce hyperpigmentation.

References

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This page is educational and is not medical advice. Compounded medications are prepared by a licensed 503(A) pharmacy and are not FDA-approved products. All treatment decisions are made by a licensed provider after reviewing your medical history.