SLU-PP-332

Also known as: ERR agonist, estrogen-related receptor agonist, exercise mimetic

WellnessWeight Management

In plain English

SLU-PP-332 is an experimental compound described as an "exercise mimetic": it switches on the same cellular pathway (the ERR receptors) that exercise activates, boosting how cells burn fat and use oxygen. In mice it increased endurance and reduced diet-induced weight gain without exercise. It has never been tested in humans, is not FDA-approved, and is strictly a research chemical.

The science

SLU-PP-332 is a synthetic pan-agonist of the estrogen-related receptors (ERRα/β/γ), orphan nuclear receptors that regulate mitochondrial biogenesis and oxidative metabolism. In mice it triggered an acute aerobic-exercise-like transcriptional response, increased fatigue resistance and running capacity, and improved metabolic parameters in models of metabolic syndrome (Billon et al., ACS Chem Biol 2023; J Pharmacol Exp Ther 2024). All evidence is preclinical; there are no human clinical trials, its oral pharmacokinetics are unfavorable, and it is not FDA-approved.

References

• Billon C et al., ACS Chem Biol 2023 (ERR agonist induces acute aerobic exercise response)
• Billon C et al., J Pharmacol Exp Ther 2024 (synthetic ERR agonist alleviates metabolic syndrome)