Topical NSAIDs (Diclofenac, Ketoprofen) & Injectable Ketorolac

Also known as: Voltaren gel (diclofenac), ketoprofen, ketorolac (injectable), nonsteroidal anti-inflammatory drugs

DermatologyOther

In plain English

These are anti-inflammatory pain relievers. Diclofenac and ketoprofen are rubbed onto painful joints or muscles (for example, arthritic knees) and relieve pain with much less stomach and body-wide risk than pills. They appear in compounded pain creams. Ketorolac is a strong injectable NSAID for short-term pain. NSAIDs still carry heart, kidney, and stomach cautions, especially with prolonged or high-dose use.

The science

NSAIDs inhibit cyclooxygenase (COX-1/COX-2), reducing prostaglandin-mediated pain and inflammation. A Cochrane review found topical diclofenac and ketoprofen significantly better than vehicle for chronic musculoskeletal (mainly knee osteoarthritis) pain, with about 60% of users achieving substantial relief and low systemic exposure. Ketorolac is a potent parenteral NSAID for short-term moderate-to-severe pain.

References

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This page is educational and is not medical advice. Compounded medications are prepared by a licensed 503(A) pharmacy and are not FDA-approved products. All treatment decisions are made by a licensed provider after reviewing your medical history.