Yohimbine

Also known as: alpha-2 adrenergic antagonist, yohimbine, yohimbine HCl, yohimbine hydrochloride

Hormone RestorationSexual Well-BeingWeight ManagementWellness

In plain English

Yohimbine is a compound from the bark of an African tree that blocks a receptor (alpha-2) which normally restrains adrenaline. It has been used for erectile dysfunction and is added to "fat-burner" products to help release stubborn fat. There is modest older evidence it can help erectile dysfunction; the fat-loss evidence is weaker. It is a stimulant that can raise blood pressure and heart rate and cause anxiety, so it is risky for people with heart conditions or anxiety and needs caution.

The science

Yohimbine is a selective alpha-2 adrenergic receptor antagonist. Blocking presynaptic alpha-2 receptors increases norepinephrine release, which can enhance lipolysis in fat depots rich in alpha-2 receptors and increase sympathetic tone; centrally it can enhance arousal and, historically, erectile function. A systematic review and meta-analysis of randomized trials found yohimbine superior to placebo for erectile dysfunction with a favorable short-term safety profile in that setting (Ernst & Pittler, 1998). Evidence for meaningful fat loss in humans is limited and inconsistent. Adverse effects include hypertension, tachycardia, anxiety, and insomnia; it is contraindicated with cardiovascular disease and anxiety disorders and interacts with numerous drugs. It is not an FDA-approved drug (prescription yohimbine was withdrawn; it persists as a supplement).

References

• Ernst & Pittler, J Urol 1998 (yohimbine for ED, meta-analysis)
• Rhim et al., J Sex Med 2019 (arginine +/- yohimbine combinations for ED)